Endocrine Abstracts

Controversy exists in the surgical treatment of patients with MEN 1 in relation to the timing and extent of interventions. Hyperparathyroidism in MEN 1 is caused by multiglandular disease and associated with high risk of supernumary glands. The findings on preoperative ultrasound and MIBI scans should not deter the surgeon from removing at least 3 parathyroid glands and the cervical thymus (1). Even subtotal parathyroidectomy (3½ glands) is associated with time dependant ...

The aims of effective surgical treatment of DTC are the provision of local control, the prevention of loco-regional relapse and when required the facilitation of adjuvant radioiodine therapy.Best practice involves a requirement to tailor the extent of thyroid and lymph node surgery to the risk of local and systemic relapse and the avoidance of over treatment and morbidity related to the laryngeal nerves and parathyroid glands. A preoperative diagnosis of...

Case history: A 36 year-old man was referred to our department for further evaluation of a large adrenal and multiple liver mass lesions. These had been found on an abdominal ultrasound requested for a 3 week history of mild, episodic abdominal pain. He was asymptomatic but described mild night sweats for over 10 years.Investigations, results and treatment: Hyperparathyroidism was evident, with a serum corrected calcium 3.04 mmol/l (2.15–2.65), PTH ...

Background: Phaeochromocytoma/paraganglioma (PCC/PGL) are rare in children and young people (CYP) under 19 years of age. National registry data reveal an annual incidence between 0.2 and 0.3 per million in 5–9 and 10–14 year age groups respectively. Almost all result from a genetic predisposition and can present a significant management challenge.Aims: We aimed to provide the first interdisciplinary management guidelines using the AGREEII frame...

A 58-year-old gentlemen presented with severe neckache, sweating, feeling hot, and cold. PMH included hypertension and MI. On examination, he was clammy, with blood pressure (BP) 205/107 mmHg. Laboratory results showed leucocytosis 28.5 and TroponinT 2002 ng/l (reference range <14.0). ECG showed inferolateral ST depression. CT angiogram showed a normal aorta and a 6 cm right adrenal mass. An echocardiogram showed severe LV impairment and normal valves.<p class="abstext...

Background: SDH mutations cause about 80% of familial pheochromocytomas / paragangliomas (1). Although mutations in each subunit are associated with a particular clinical spectrum of disease, there is no clear genotype-phenotype correlation of a specific mutation, nor with penetrance of disease. We report characteristics of patients with SDH mutations seen in a single dedicated tertiary referral clinic.Methods: A retrospective observational study of pati...

Aims: Although rare, craniopharyngiomas are the commonest suprasellar tumour in childhood. Despite high overall survival, children and young people <19 years with craniopharyngiomas are at risk of multiple relapses and long-term tumour- and treatment-related morbidity. We sought to provide, for the first time, a national standard for best practice based on currently available evidence for the assessment, treatment and follow-up of paediatric craniopharyngiomas under the au...